3h]-ekc (New England Nuclear Corporation)
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Structured Review
New England Nuclear Corporation
3h]-ekc
3h] Ekc, supplied by New England Nuclear Corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/3h%5Dekc/3h++ekc/pm11861808-142-14-20
Average 90 stars, based on 1 article reviews
3h] Ekc, supplied by New England Nuclear Corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/3h%5Dekc/3h++ekc/pm11861808-142-14-20
Average 90 stars, based on 1 article reviews
3h]-ekc - by Bioz Stars,
2026-09
90/100 stars
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Binding Assay:Article Title: Determinants of ligand selectivity at the kappa-receptor based on the structure of the orphanin FQ receptor. Article Snippet: It is unclear how opioid selectivity and activation are regulated within the receptor core.. In previous studies, the OFQ receptor was converted into a functional opioid receptor by mutating five amino acids at three sites to the corresponding residues conserved across the -, -, and -opioid receptors, suggesting that these sites comprise an opioid binding pocket.. To examine this hypothesis, the present study examines whether these conserved residues represent an opioid binding pocket in the context of the opioid receptors, i.e., does their removal from opioid receptors destroy opioid ligand binding? Article Title: Key residues defining the mu-opioid receptor binding pocket: a site-directed mutagenesis study. Article Snippet: The p-opioid Article Title: Effects of ovarian steroids on hypothalamic opioid receptor subtypes in ovariectomized ewes: regional changes in density and affinity. Article Snippet: The negative feedback regulation by ovarian steroids of luteinizing hormone secretion may be partially mediated by a hypothalamic endogenous opioid mechanism.. This could be affected by ovarian steroid-regulated changes in hypothalamic opioid receptor binding mechanisms.. In this report we show that in the presence of blocking concentrations of site-selective opioid analogues, [3H]diprenorphin homogeneously labelled \g=m\,\g=d\or \g=k\receptor subtypes respectively. Article Title: Separation of kappa-opioid receptor subtype from frog brain. Article Snippet: [9-3H]Ethylketocyclazocine ([3H]EKC: 0.74 TBq/mmol; 19.9 Article Title: Syndyphalin SD-25: a highly selective ligand for mu opiate receptors. Article Snippet: After the discovery of the enkephalin [ 11, it was reported [2] that the order of potency for morphine and the enkephalins was inversed in the mouse vas deferens (in comparison with the guinea pig ileum), thus suggesting the existence of various class of opiate receptors.. However, a major problem in the precise characterization of the different receptors has been the absence of very selective ligands for one peculiar subclass of opiate receptors.. In [3] morphiceptin, the amide of a fragment of the milk protein fl-casein, was suggested to represent a highly selective ligand for the p opiate receptor. Article Title: Dynorphin A(1-8) in human placenta: amino acid sequence determined by tandem mass spectrometry. Article Snippet: AGBAS, A., M. S. AHMED, W. MILLINGTON, B. CEMERKIC, D. M. DESIDERIO, J.-L. TSENG AND C. DASS.. Dynorphin A(1 -8) in human placenta: Amino acid sequence determined by tandem mass spectrometty.. PEPTIDES 16(4) 623-627, 1995.Presence of the K receptor-preferring neuropeptide dynorphin A( l-8) in human placenta has been demonstrated by mass spectrometry to establish rigorously the appropriate molecular weight and amino acid sequence. Article Title: Modulation of mu, kappa and delta opioid receptors in the rat brain by isoflurane and enflurane. Article Snippet: This study was done to investigate whether inhalational anesthetics modulated the binding of specific ligands to opioid receptors in the brain of the rat.. The effect of isoflurane and enflurane on the binding of specific ligands to various subtypes of opioid receptors in vitro was studied.. Isoflurane inhibited the binding of [3H]naloxone to opioid receptors by 50% in the spinal cord, midbrain and cortex at 22, 49 and 50mM, respectively. Membrane:Article Title: Determinants of ligand selectivity at the kappa-receptor based on the structure of the orphanin FQ receptor. Article Snippet: It is unclear how opioid selectivity and activation are regulated within the receptor core.. In previous studies, the OFQ receptor was converted into a functional opioid receptor by mutating five amino acids at three sites to the corresponding residues conserved across the -, -, and -opioid receptors, suggesting that these sites comprise an opioid binding pocket.. To examine this hypothesis, the present study examines whether these conserved residues represent an opioid binding pocket in the context of the opioid receptors, i.e., does their removal from opioid receptors destroy opioid ligand binding? Article Title: Key residues defining the mu-opioid receptor binding pocket: a site-directed mutagenesis study. Article Snippet: The p-opioid Article Title: Effects of ovarian steroids on hypothalamic opioid receptor subtypes in ovariectomized ewes: regional changes in density and affinity. Article Snippet: The negative feedback regulation by ovarian steroids of luteinizing hormone secretion may be partially mediated by a hypothalamic endogenous opioid mechanism.. This could be affected by ovarian steroid-regulated changes in hypothalamic opioid receptor binding mechanisms.. In this report we show that in the presence of blocking concentrations of site-selective opioid analogues, [3H]diprenorphin homogeneously labelled \g=m\,\g=d\or \g=k\receptor subtypes respectively. Article Title: Separation of kappa-opioid receptor subtype from frog brain. Article Snippet: [9-3H]Ethylketocyclazocine ([3H]EKC: 0.74 TBq/mmol; 19.9 Article Title: Syndyphalin SD-25: a highly selective ligand for mu opiate receptors. Article Snippet: After the discovery of the enkephalin [ 11, it was reported [2] that the order of potency for morphine and the enkephalins was inversed in the mouse vas deferens (in comparison with the guinea pig ileum), thus suggesting the existence of various class of opiate receptors.. However, a major problem in the precise characterization of the different receptors has been the absence of very selective ligands for one peculiar subclass of opiate receptors.. In [3] morphiceptin, the amide of a fragment of the milk protein fl-casein, was suggested to represent a highly selective ligand for the p opiate receptor. Article Title: Dynorphin A(1-8) in human placenta: amino acid sequence determined by tandem mass spectrometry. Article Snippet: AGBAS, A., M. S. AHMED, W. MILLINGTON, B. CEMERKIC, D. M. DESIDERIO, J.-L. TSENG AND C. DASS.. Dynorphin A(1 -8) in human placenta: Amino acid sequence determined by tandem mass spectrometty.. PEPTIDES 16(4) 623-627, 1995.Presence of the K receptor-preferring neuropeptide dynorphin A( l-8) in human placenta has been demonstrated by mass spectrometry to establish rigorously the appropriate molecular weight and amino acid sequence. Article Title: Modulation of mu, kappa and delta opioid receptors in the rat brain by isoflurane and enflurane. Article Snippet: This study was done to investigate whether inhalational anesthetics modulated the binding of specific ligands to opioid receptors in the brain of the rat.. The effect of isoflurane and enflurane on the binding of specific ligands to various subtypes of opioid receptors in vitro was studied.. Isoflurane inhibited the binding of [3H]naloxone to opioid receptors by 50% in the spinal cord, midbrain and cortex at 22, 49 and 50mM, respectively. Labeling:Article Title: Determinants of ligand selectivity at the kappa-receptor based on the structure of the orphanin FQ receptor. Article Snippet: It is unclear how opioid selectivity and activation are regulated within the receptor core.. In previous studies, the OFQ receptor was converted into a functional opioid receptor by mutating five amino acids at three sites to the corresponding residues conserved across the -, -, and -opioid receptors, suggesting that these sites comprise an opioid binding pocket.. To examine this hypothesis, the present study examines whether these conserved residues represent an opioid binding pocket in the context of the opioid receptors, i.e., does their removal from opioid receptors destroy opioid ligand binding? Article Title: Key residues defining the mu-opioid receptor binding pocket: a site-directed mutagenesis study. Article Snippet: The p-opioid Article Title: Effects of ovarian steroids on hypothalamic opioid receptor subtypes in ovariectomized ewes: regional changes in density and affinity. Article Snippet: The negative feedback regulation by ovarian steroids of luteinizing hormone secretion may be partially mediated by a hypothalamic endogenous opioid mechanism.. This could be affected by ovarian steroid-regulated changes in hypothalamic opioid receptor binding mechanisms.. In this report we show that in the presence of blocking concentrations of site-selective opioid analogues, [3H]diprenorphin homogeneously labelled \g=m\,\g=d\or \g=k\receptor subtypes respectively. Article Title: Separation of kappa-opioid receptor subtype from frog brain. Article Snippet: [9-3H]Ethylketocyclazocine ([3H]EKC: 0.74 TBq/mmol; 19.9 Article Title: Syndyphalin SD-25: a highly selective ligand for mu opiate receptors. Article Snippet: After the discovery of the enkephalin [ 11, it was reported [2] that the order of potency for morphine and the enkephalins was inversed in the mouse vas deferens (in comparison with the guinea pig ileum), thus suggesting the existence of various class of opiate receptors.. However, a major problem in the precise characterization of the different receptors has been the absence of very selective ligands for one peculiar subclass of opiate receptors.. In [3] morphiceptin, the amide of a fragment of the milk protein fl-casein, was suggested to represent a highly selective ligand for the p opiate receptor. Article Title: Dynorphin A(1-8) in human placenta: amino acid sequence determined by tandem mass spectrometry. Article Snippet: AGBAS, A., M. S. AHMED, W. MILLINGTON, B. CEMERKIC, D. M. DESIDERIO, J.-L. TSENG AND C. DASS.. Dynorphin A(1 -8) in human placenta: Amino acid sequence determined by tandem mass spectrometty.. PEPTIDES 16(4) 623-627, 1995.Presence of the K receptor-preferring neuropeptide dynorphin A( l-8) in human placenta has been demonstrated by mass spectrometry to establish rigorously the appropriate molecular weight and amino acid sequence. Article Title: Modulation of mu, kappa and delta opioid receptors in the rat brain by isoflurane and enflurane. Article Snippet: This study was done to investigate whether inhalational anesthetics modulated the binding of specific ligands to opioid receptors in the brain of the rat.. The effect of isoflurane and enflurane on the binding of specific ligands to various subtypes of opioid receptors in vitro was studied.. Isoflurane inhibited the binding of [3H]naloxone to opioid receptors by 50% in the spinal cord, midbrain and cortex at 22, 49 and 50mM, respectively. Activity Assay:Article Title: Determinants of ligand selectivity at the kappa-receptor based on the structure of the orphanin FQ receptor. Article Snippet: It is unclear how opioid selectivity and activation are regulated within the receptor core.. In previous studies, the OFQ receptor was converted into a functional opioid receptor by mutating five amino acids at three sites to the corresponding residues conserved across the -, -, and -opioid receptors, suggesting that these sites comprise an opioid binding pocket.. To examine this hypothesis, the present study examines whether these conserved residues represent an opioid binding pocket in the context of the opioid receptors, i.e., does their removal from opioid receptors destroy opioid ligand binding? Article Title: Key residues defining the mu-opioid receptor binding pocket: a site-directed mutagenesis study. Article Snippet: The p-opioid Article Title: Effects of ovarian steroids on hypothalamic opioid receptor subtypes in ovariectomized ewes: regional changes in density and affinity. Article Snippet: The negative feedback regulation by ovarian steroids of luteinizing hormone secretion may be partially mediated by a hypothalamic endogenous opioid mechanism.. This could be affected by ovarian steroid-regulated changes in hypothalamic opioid receptor binding mechanisms.. In this report we show that in the presence of blocking concentrations of site-selective opioid analogues, [3H]diprenorphin homogeneously labelled \g=m\,\g=d\or \g=k\receptor subtypes respectively. Article Title: Separation of kappa-opioid receptor subtype from frog brain. Article Snippet: [9-3H]Ethylketocyclazocine ([3H]EKC: 0.74 TBq/mmol; 19.9 Article Title: Syndyphalin SD-25: a highly selective ligand for mu opiate receptors. Article Snippet: After the discovery of the enkephalin [ 11, it was reported [2] that the order of potency for morphine and the enkephalins was inversed in the mouse vas deferens (in comparison with the guinea pig ileum), thus suggesting the existence of various class of opiate receptors.. However, a major problem in the precise characterization of the different receptors has been the absence of very selective ligands for one peculiar subclass of opiate receptors.. In [3] morphiceptin, the amide of a fragment of the milk protein fl-casein, was suggested to represent a highly selective ligand for the p opiate receptor. Article Title: Dynorphin A(1-8) in human placenta: amino acid sequence determined by tandem mass spectrometry. Article Snippet: AGBAS, A., M. S. AHMED, W. MILLINGTON, B. CEMERKIC, D. M. DESIDERIO, J.-L. TSENG AND C. DASS.. Dynorphin A(1 -8) in human placenta: Amino acid sequence determined by tandem mass spectrometty.. PEPTIDES 16(4) 623-627, 1995.Presence of the K receptor-preferring neuropeptide dynorphin A( l-8) in human placenta has been demonstrated by mass spectrometry to establish rigorously the appropriate molecular weight and amino acid sequence. Article Title: Modulation of mu, kappa and delta opioid receptors in the rat brain by isoflurane and enflurane. Article Snippet: This study was done to investigate whether inhalational anesthetics modulated the binding of specific ligands to opioid receptors in the brain of the rat.. The effect of isoflurane and enflurane on the binding of specific ligands to various subtypes of opioid receptors in vitro was studied.. Isoflurane inhibited the binding of [3H]naloxone to opioid receptors by 50% in the spinal cord, midbrain and cortex at 22, 49 and 50mM, respectively. Digital Holographic Microscopy:Article Title: Determinants of ligand selectivity at the kappa-receptor based on the structure of the orphanin FQ receptor. Article Snippet: It is unclear how opioid selectivity and activation are regulated within the receptor core.. In previous studies, the OFQ receptor was converted into a functional opioid receptor by mutating five amino acids at three sites to the corresponding residues conserved across the -, -, and -opioid receptors, suggesting that these sites comprise an opioid binding pocket.. To examine this hypothesis, the present study examines whether these conserved residues represent an opioid binding pocket in the context of the opioid receptors, i.e., does their removal from opioid receptors destroy opioid ligand binding? Article Title: Key residues defining the mu-opioid receptor binding pocket: a site-directed mutagenesis study. Article Snippet: The p-opioid Article Title: Effects of ovarian steroids on hypothalamic opioid receptor subtypes in ovariectomized ewes: regional changes in density and affinity. Article Snippet: The negative feedback regulation by ovarian steroids of luteinizing hormone secretion may be partially mediated by a hypothalamic endogenous opioid mechanism.. This could be affected by ovarian steroid-regulated changes in hypothalamic opioid receptor binding mechanisms.. In this report we show that in the presence of blocking concentrations of site-selective opioid analogues, [3H]diprenorphin homogeneously labelled \g=m\,\g=d\or \g=k\receptor subtypes respectively. Article Title: Separation of kappa-opioid receptor subtype from frog brain. Article Snippet: [9-3H]Ethylketocyclazocine ([3H]EKC: 0.74 TBq/mmol; 19.9 Article Title: Syndyphalin SD-25: a highly selective ligand for mu opiate receptors. Article Snippet: After the discovery of the enkephalin [ 11, it was reported [2] that the order of potency for morphine and the enkephalins was inversed in the mouse vas deferens (in comparison with the guinea pig ileum), thus suggesting the existence of various class of opiate receptors.. However, a major problem in the precise characterization of the different receptors has been the absence of very selective ligands for one peculiar subclass of opiate receptors.. In [3] morphiceptin, the amide of a fragment of the milk protein fl-casein, was suggested to represent a highly selective ligand for the p opiate receptor. Article Title: Dynorphin A(1-8) in human placenta: amino acid sequence determined by tandem mass spectrometry. Article Snippet: AGBAS, A., M. S. AHMED, W. MILLINGTON, B. CEMERKIC, D. M. DESIDERIO, J.-L. TSENG AND C. DASS.. Dynorphin A(1 -8) in human placenta: Amino acid sequence determined by tandem mass spectrometty.. PEPTIDES 16(4) 623-627, 1995.Presence of the K receptor-preferring neuropeptide dynorphin A( l-8) in human placenta has been demonstrated by mass spectrometry to establish rigorously the appropriate molecular weight and amino acid sequence. Article Title: Modulation of mu, kappa and delta opioid receptors in the rat brain by isoflurane and enflurane. Article Snippet: This study was done to investigate whether inhalational anesthetics modulated the binding of specific ligands to opioid receptors in the brain of the rat.. The effect of isoflurane and enflurane on the binding of specific ligands to various subtypes of opioid receptors in vitro was studied.. Isoflurane inhibited the binding of [3H]naloxone to opioid receptors by 50% in the spinal cord, midbrain and cortex at 22, 49 and 50mM, respectively. |